Major Criteria
Blood culture positive for IE
Typical microorganisms consistent with IE from 2 separate blood cultures, or persistently positive blood cultures
Evidence of endocardial involvement
Echocardiogram positive for IE or new valvular regurgitation
Minor Criteria
Predisposition
Predisposing heart condition or injection drug use
Fever
Temperature ≥ 38.0°C (100.4°F)
Vascular phenomena
Major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, Janeway lesions
Immunologic phenomena
Glomerulonephritis, Osler nodes, Roth spots, rheumatoid factor
Microbiological evidence
Positive blood culture but does not meet a major criterion or serological evidence of active infection with organism consistent with IE
Pathological Criteria
Microorganisms demonstrated by culture or histologic examination
of a vegetation, a vegetation that has embolized, or an intracardiac abscess specimen
Pathologic lesions
vegetation or intracardiac abscess confirmed by histologic examination showing active endocarditis
Duke Criteria: Rejected
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Instructions
The Duke Criteria are used to help diagnose infective endocarditis (IE) by combining clinical, microbiological, and echocardiographic findings. It categorizes cases as definite, possible, or rejected endocarditis, guiding diagnosis and management.
Frequently Asked Questions
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Can Duke Criteria be used alone to diagnose endocarditis?+
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Can they be used in prosthetic valve endocarditis?+
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