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Home/Diagnosis/ICD-10 Coding for HLA-B27 Positive

ICD-10 Coding for HLA-B27 Positive

Z15.89
M45

Complete ICD-10-CM coding and documentation guide for icd-10 coding for hla-b27 positive includes clinical validation requirements, medical necessity guidelines, and coding policies.

Also Known as:
Human Leukocyte Antigen B27 Positive
HLA-B27 Carrier
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Key Information: ICD-10 Coding for HLA-B27 Positive

Essential facts and insights about ICD-10 Coding for HLA-B27 Positive

Use ICD-10 code Z15.89 for genetic susceptibility to other disease, ensuring proper documentation in clinical notes.

Primary ICD-10-CM Codes

Genetic susceptibility to other disease

Billable Code
Z15.89
Billable

Diagnostic Criteria

clinical:
  • • HLA-B27 positivity confirmed by lab testing
documentation:
  • • Family history or clinical suspicion documented

Applicable To

  • • HLA-B27 positive status

Important Notes

  • • Ensure documentation supports genetic susceptibility rather than active disease.

Ankylosing spondylitis

Non-Billable
M45
Non-Billable

Diagnostic Criteria

clinical:
  • • Radiographic evidence of sacroiliitis
  • • Symptoms of inflammatory back pain

Applicable To

  • • Spondyloarthritis associated with HLA-B27

Important Notes

  • • Ensure imaging supports the diagnosis.
Ancillary Codes

Additional codes that may be used with this diagnosis

H20.01

Anterior uveitis

Use with Z15.89 when HLA-B27 is linked to recurrent uveitis.

Frequently Asked Questions

What is the ICD-10 code for HLA-B27 positive?

The ICD-10 code for HLA-B27 positive is Z15.89, indicating genetic susceptibility to other diseases.

How is HLA-B27 positivity documented?

HLA-B27 positivity should be documented with the testing method, such as PCR, and linked to clinical findings or family history.

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