D81

Classification

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Coding Guidance

D81 should not be used for reimbursement purposes as there are more specific codes below it that contain a greater level of detail.

Includes

From C00-D49

Excludes 1

More Specific Codes

D81.0

Severe combined immunodeficiency [SCID] with reticular dysgenesis

D81.1

Severe combined immunodeficiency [SCID] with low T- and B-cell numbers

D81.2

Severe combined immunodeficiency [SCID] with low or normal B-cell numbers

D81.3

Adenosine deaminase [ADA] deficiency

D81.4

Nezelof's syndrome

D81.5

Purine nucleoside phosphorylase [PNP] deficiency

D81.6

Major histocompatibility complex class I deficiency

D81.7

Major histocompatibility complex class II deficiency

D81.8

Other combined immunodeficiencies

D81.9

Combined immunodeficiency, unspecified

External Resources

2025 ICD-10 guidelines from CMS.gov